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In this article, we are going to review the Brad Pitt of artificial sweeteners, aspartame. Aspartame is the combination of two amino acids. It was approved by the Food and Drug Administration (FDA) in the 80s and there has been research on this sweet amino since the 70s, let look at some of the findings:

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THE FACTS

  • The question was raised on the chemical’s potential neurotoxicity [1][2][3]
  • Suggested linkage to brain tumor rates [4]
  • Demonstrated that aspartame can significantly increase brain phenylalanine and tyrosine levels, and can suppress the usual increase in tryptophan that follows a carbohydrate rich meal. [5] This has been linked too:
    • Seizures [6][7][8]
    • Mood Disorders [7][9][10]
    • Headaches [11]
    • And negative effects on appetite [12].
  • BUT WAIT! There are some good findings that support aspartame, and the great news is that many of these studies were sponsored by industry…, the companies making money from aspartame.

REFERENCES

  1. Anderson, GH. Leiter, LA. Effects of aspartame and phenylalanine on meal-time food intake of humans. Appetite. 11(s):48-53. 1988.
  2. Anderson, GH. Ryan-Harshman, M. Leiter, LA. Phenylalanine and aspartame fail to alter feeding behavior in adult males. Fed Proc. 45:590. 1986.
  3. Aspinall, RL. Saunders, PM. Pautxch, WF. Nutting, EF. The biological properties of aspartame v. effects on a variety of physiological parameters related to inflammation and metabolism. J Environ Pathol Toxicol. 3:387-395. 1980.
  4. Baker, GL. Filer, LJ. Brummel, MC. Stegink, LD. Effect of aspartame loading upon plasma and red cell free amino acid. Fed Proc. 36:497. 1976.
  5. Baker, GL. Filer, LJ. Stegink, LD. Plasma and erythrocyte amino acid levels in normal adults fed high protein meals: effect of added monosodium glutamate or monosodium glutamate plus aspartame. Fed Proc. 36:1154. 1977.
  6. Baker, GL. Filer, LJ. Stegink, LD. Plasma, red cell and breast milk —- amino acid levels in lactating women administered aspartame or lactose at 50 mg/kg body weight. J Nutri 106(7):xxxiii. 1976.
  7. Baraniuk, JN. Follett, JV. Schiffman, SS. Massey, EW. Sampson, HA. Warwick, ZS. Buckley, CE. Immunophysiologic correlates of cutaneous histamine reactivity in patients with alleged aspartame sensitivity. J Allergy Clin Immunol. 81(1):187. 1988.
  8. Bauer-Nehrling, JK. McLane, MP. Kobe, PJ. Kamath, SK. Horwitz, DL. Evaluation of aspartame in diabetes control. Diabetes. 32(s1):A64. 1983.
  9. Belger, A. Stokes, AF. Taylor, H. Banich, MT. Effects of acute aspartame ingestion upon the cognitive performance of pilots. Aviat Space Environ. Med May:-
  10. Benninger, C. Matthis, P. deSonneville, L. Lanz-Englert, B. Trefz, F. Bickel, H. Chronic high-dose aspartame ingestion does not affect electroencephalogram (EEG) spectral parameters in phenylketonuric heterozygotes. J Clin Exp Neuropsychol. 15(3):407. 1993.
  11. Benninger, C. Matthis, P. deSonneville, LMJ. Lanz-Englert, B. Trefz, FK. Bickel, H. High dose aspartame has no effect on EEC spectral parameters in phenylketonuric heterozygotes (PKUH). Soc Neurosci Abstr 17:504. 1991.
  12. Benninger, CK. Matthis, P. deSonneville, LMJ. Lanz-Englert, B. Trefz, FK. Bickel, H. Electro-encephalographic evaluation of chronic aspartame ingestion in phenylketonuric heterozygotes (PKUH). Electroencephalogr Clin Neurophysiol. 2:S58. 1993.
  13. Briffa J. Aspartame and its effects on health: Independently funded studies have found potential for adverse effects. BMJ : British Medical Journal. 2005;330(7486):309-310.

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